Ethanol → Ethyl 3-Bromo-5-fluorobenzoate
反応式
S(=O)(=O)(O)O.[Br:6][C:7]1[CH:8]=[C:9]([CH:13]=[C:14]([F:16])[CH:15]=1)[C:10]([OH:12])=[O:11].[CH2:17](O)[CH3:18]>C(OCC)C.O>[Br:6][C:7]1[CH:8]=[C:9]([CH:13]=[C:14]([F:16])[CH:15]=1)[C:10]([O:12][CH2:17][CH3:18])=[O:11]参加物
6
実験手順
Sulphuric acid (0.5 mL) was added to a stirring solution of 3-bromo-5-fluorobenzoic acid (473 mgs, 2.16 mmol) in ethanol (10 mL) and refluxed for 17 hours. The reaction mixture was cooled to room temperature and diluted with diethyl ether and water. The ether layer was washed with 5% sodium hydrogen carbonate solution, dried over magnesium sulphate and evaporated to dryness to give the title compound as a brown oil. (506 mg).
後処理
- temperaturerefluxed for 17 hours
- washThe ether layer was washed with 5% sodium hydrogen carbonate solution
- dry with materialdried over magnesium sulphate
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-b5ddce8d41944fb2a45960cd69bface4
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07446222B2
反応ノート
読み込み中…