関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Toluene ethanol | HCID 21863594 | — |
| 反応物 | Ethyl 2-bromo-4-chlorobenzoate | HCID 53216606 | — |
| 反応物 | 2'-Benzyloxy-biphenyl-2-boronic acid | HCID 58730990 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Ethyl 5-chloro-2''-[(phenylmethyl)oxy]-1,1':2',1''-terphenyl-2-carboxylate | HCID 58731013 | — |
反応手順
A mixture of 2′-benzyloxybiphenyl boronic acid (50 mg, 0.16 mmol), ethyl 2-bromo-4-chlorobenzoate (66 mg, 0.25 mmol), potassium carbonate (88 mg, 0.64 mmol) and tetrakis(triphenylphosphine)palladium(0) (10 mg, 5 mol %) in 1:1 toluene/ethanol (2 ml) was stirred and heated at 90° C. under nitrogen for 12 hours. After cooling the mixture was diluted with diethyl ether and water and the organic phase dried (MgSO4) and evaporated to dryness. The residue was chromatographed with ethyl acetate/iso-hexane (1:9) to yield the title compound as a pale yellow gum. (46 mg, 66%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07446222B2 |
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| 出典データセット | uspto-grants-2008_11 |
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| ORD ID | ord-a36b5c992b014a60a613a74fb93c144b |
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| 出典メモ | uspto-grants-2008_11 |
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