Benzyl Bromide → 2-(Benzyloxy)-3-bromo-5-chloropyridine

HRID 269581ノート

反応式

HRID 269581 の反応式
[Br:1][C:2]1[C:3]([OH:9])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:10](Br)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1.C(=O)([O-])[O-].[Ag+2]>[CH2:10]([O:9][C:3]1[C:2]([Br:1])=[CH:7][C:6]([Cl:8])=[CH:5][N:4]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

5

反応物 2

HCID 7498Benzyl BromideHCID 178517755HCID 178517755、化合物

生成物 1

HCID 220583822-(Benzyloxy)-3-bromo-5-chloropyridine

試薬・触媒・溶媒 2

HCID 178418647HCID 178418647、化合物触媒HCID 1140Toluene溶媒

実験手順

3-Bromo-5-chloro-2-pyridinol (7.0 g, 33.6 mmol) was stirred in toluene (160 ml) and silver carbonate (10.23 g, 36.9 mmol) added, followed by benzyl bromide (6.32 g, 4.39 ml, 36.9 mmol). The mixture was heated to reflux for 1 hour. After cooling, the mixture was filtered, washed with water (×2), dried (MgSO4) and evaporated. The residue was triturated with isohexane and the pale yellow solid filtered and dried. (8.36 g).

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 1 hour
  3. temperatureAfter cooling
  4. filtrationthe mixture was filtered
  5. washwashed with water (×2)
  6. dry with materialdried (MgSO4)
  7. customevaporated
  8. customThe residue was triturated with isohexane
  9. filtrationthe pale yellow solid filtered
  10. customdried

出典と根拠

ORDレコード
ord-d4369e9f678b4d7381f563c85bf92a92
出典データセット
uspto-grants-2008_11
特許番号
US07446222B2

反応ノート

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