関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl 5-bromopyridine-3-carboxylate | HCID 140785 | — |
| 反応物 | 2'-Benzyloxy-biphenyl-2-boronic acid | HCID 58730990 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Diethylether water | HCID 21584184 | — |
| 生成物 | Ethyl 5-{2'-[(phenylmethyl)oxy]-2-biphenylyl}-3-pyridinecarboxylate | HCID 58730994 | 80.6% |
反応手順
A mixture of ethyl 5-bromonicotinate (46 mg, 0.2 mmol), {2′-[(phenylmethyl)oxy]-2-biphenylyl}boronic acid (61 mg, 0.2 mmol), potassium carbonate (221 mg, 1.6 mmol) and tetrakis(triphenylphosphine)palladium(0) (23 mg, 0.02 mmol) was stirred and heated at 90° C. under nitrogen for 2 hours. After cooling the mixture was diluted with ether/water and the organic phase dried (magnesium sulphate), evaporated and chromatographed on silica eluting with ethyl acetate/iso-hexane (1:5) to give 66 mg of colourless gum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07446222B2 |
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| 出典データセット | uspto-grants-2008_11 |
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| ORD ID | ord-42d232ef5de84170bcdcc8a7f6ebcff4 |
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| 出典メモ | uspto-grants-2008_11 |
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