Benzyl Bromide → HCID 67058419、化合物

HRID 269588ノート

反応式

HRID 269588 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[CH2:10](Br)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 132842722-Bromo-5-chlorophenol

生成物 1

HCID 67058419HCID 67058419、化合物収率 97.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2-bromo-5-chlorophenol (3.93 g, 18.94 mmol), benzyl bromide (3.42 g, 20 mmol) and potassium carbonate (10 g, 72.46 mmol) in acetone (80 ml) was stirred and refluxed for 3 hours then cooled, evaporated and dissolved in ether/water. The organic phase was dried (magnesium sulphate) evaporated and purified by chromatography on silica eluting with ethyl acetate/iso-hexane (1:99) to give 5.51 g of white solid.

後処理

  1. temperaturerefluxed for 3 hours
  2. temperaturethen cooled
  3. customevaporated
  4. dissolutiondissolved in ether/water
  5. dry with materialThe organic phase was dried (magnesium sulphate)
  6. customevaporated
  7. custompurified by chromatography on silica eluting with ethyl acetate/iso-hexane (1:99)

出典と根拠

ORDレコード
ord-d9292a6cf0e542dea94b01ff32c6b94e
出典データセット
uspto-grants-2008_11
特許番号
US07446222B2

反応ノート

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