Triethylamine → (2S)-2,4-Bis[(tert-butoxycarbonyl)amino]butyl methanesulphonate

HRID 269617ノート

反応式

HRID 269617 の反応式
[C:1]([O:5][C:6](=[O:21])[NH:7][CH2:8][CH2:9][C@H:10]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:11][OH:12])([CH3:4])([CH3:3])[CH3:2].[CH3:22][S:23](Cl)(=[O:25])=[O:24].C(N(CC)CC)C>ClCCl>[CH3:22][S:23]([O:12][CH2:11][C@@H:10]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:9][CH2:8][NH:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:21])(=[O:25])=[O:24]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 57440192HCID 57440192、化合物

生成物 1

HCID 86601681(2S)-2,4-Bis[(tert-butoxycarbonyl)amino]butyl methanesulphonate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Preparation takes place in analogy to Example 84A from 250 mg (0.81 mmol) of tert-butyl{(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutyl}carbamate (Example 89A) in 20 ml of dichloromethane with 110 mg (0.97 mmol) of methanesulfonyl chloride and 0.23 ml (1.6 mmol) of triethylamine. The product is reacted without further purification.

後処理

  1. customPreparation
  2. customThe product is reacted without further purification

出典と根拠

ORDレコード
ord-66dc4b91028b4aafb09346fd1ff872a6
出典データセット
uspto-grants-2008_11
特許番号
US07446102B2

反応ノート

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