Hydrochloric Acid → HCID 178479349、化合物

HRID 269629ノート

反応式

HRID 269629 の反応式
[CH2:1]([O:8][C:9](=[O:42])[NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:41])[C@H:15]([CH2:24][CH2:25][CH2:26][NH:27][C:28]([NH:30][C:31]([O:33]CC1C=CC=CC=1)=[O:32])=[NH:29])[NH:16]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:43]>O1CCOCC1>[ClH:43].[CH2:1]([N:30]([C:28](=[NH:29])[NH:27][CH2:26][CH2:25][CH2:24][C@H:15]([NH2:16])[C:14](=[O:41])[NH:13][CH2:12][CH2:11][NH:10][C:9](=[O:42])[O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:31](=[O:32])[OH:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 178454188HCID 178454188、化合物

生成物 1

HCID 178479349HCID 178479349、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 334 mg (0.417 mmol) of benzyl (2-{[N5-[{[(benzyloxy)carbonyl]amino}(imino)methyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}ethyl)carbamate (Example 102A) and 17 ml of a 4M solution of hydrogen chloride in dioxane is stirred at RT for 4 h. The reaction solution is concentrated, coevaporated with dichloromethane several times, and dried under high vacuum. The crude product is reacted without further purification.

後処理

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

出典と根拠

ORDレコード
ord-3ff67b89f62c45d486058ea0410e3575
出典データセット
uspto-grants-2008_11
特許番号
US07446102B2

反応ノート

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