Hydrochloric Acid → benzyl((1S)-4-amino-1-{2-[(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-oxoethyl}butyl)carbamate hydrochloride

HRID 269631ノート

反応式

HRID 269631 の反応式
[ClH:1].[CH2:2]([O:9][C:10](=[O:41])[NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:40])[CH2:16][C@@H:17]([NH:29][C:30]([O:32]CC1C=CC=CC=1)=[O:31])[CH2:18][CH2:19][CH2:20][NH:21]C(OC(C)(C)C)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([N:29]([C@H:17]([CH2:16][C:15]([NH:14][CH2:13][CH2:12][NH:11][C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:41])=[O:40])[CH2:18][CH2:19][CH2:20][NH2:21])[C:30](=[O:31])[OH:32])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86624500HCID 86624500、化合物

生成物 1

HCID 69216382benzyl((1S)-4-amino-1-{2-[(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-oxoethyl}butyl)carbamate hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

8 ml of a 4M solution of hydrogen chloride in dioxane are added to a solution of 320 mg (0.287 mmol) of benzyl[2-({(3S)-3-{[(benzyloxy)carbonyl]amino}-6-[(tert-butoxycarbonyl)amino]hexanoyl}amino)ethyl]carbamate (Example 104A) in 2 ml of dioxane at 0° C. After 1 h at RT, the reaction solution is concentrated in vacuo, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

後処理

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

出典と根拠

ORDレコード
ord-16282749c19d4fb582becedfe43dd038
出典データセット
uspto-grants-2008_11
特許番号
US07446102B2

反応ノート

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