Hydrochloric Acid → HCID 69216959、化合物

HRID 269633ノート

反応式

HRID 269633 の反応式
[ClH:1].[CH2:2]([O:9][C:10](=[O:59])[NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:58])[CH2:16][C@@H:17]([NH:47][C:48]([O:50][CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:49])[CH2:18][CH2:19][CH2:20][NH:21][C:22](=[O:46])[C@H:23]([CH2:32][CH2:33][CH2:34][NH:35][C:36]([O:38]CC1C=CC=CC=1)=[O:37])[NH:24]C(OC(C)(C)C)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([N:35]([CH2:34][CH2:33][CH2:32][C@H:23]([NH2:24])[C:22](=[O:46])[NH:21][CH2:20][CH2:19][CH2:18][C@H:17]([NH:47][C:48]([O:50][CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:49])[CH2:16][C:15](=[O:58])[NH:14][CH2:13][CH2:12][NH:11][C:10](=[O:59])[O:9][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[C:36](=[O:37])[OH:38])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86624503Benzyl {2-[((3S)-3-{[(benzyloxy)carbonyl]amino}-6-{[N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}hexanoyl)amino]ethyl}carbamate

生成物 1

HCID 69216959HCID 69216959、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

2.5 ml of a 4M solution of hydrogen chloride in dioxane are added to a solution of 48 mg (0.060 mmol) of benzyl{2-[((3S)-3-{[(benzyloxy)carbonyl]amino}-6-{[N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}hexanoyl)amino]ethyl}carbamate (Example 106A) in 1 ml of dioxane at RT. After 4 h at RT, the reaction solution is concentrated in vacuo, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

後処理

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

出典と根拠

ORDレコード
ord-573c722c852946eab2101eaa90bcdd2b
出典データセット
uspto-grants-2008_11
特許番号
US07446102B2

反応ノート

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