Piperidine → tert-butyl[(1S)-4-[(tert-butoxycarbonyl)amino]-1-({[(2s)-2,5-diamino-5-oxopentanoyl]amino}methyl)butyl]carbamate
反応式
C1C2C(COC(=O)[NH:17][C@H:18]([C:24]([NH:26][CH2:27][C@@H:28]([NH:40][C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=[O:25])[CH2:19][CH2:20][C:21]([NH2:23])=[O:22])C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>CN(C)C=O>[C:44]([O:43][C:41](=[O:42])[NH:40][C@H:28]([CH2:27][NH:26][C:24](=[O:25])[C@@H:18]([NH2:17])[CH2:19][CH2:20][C:21]([NH2:23])=[O:22])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:34])([CH3:45])([CH3:46])[CH3:47]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
A solution of 33 mg (0.05 mmol) of 9H-fluoren-9-ylmethyl{(1S)-4-amino-1-[({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)carbonyl]-4-oxobutyl}carbamate (Example 129A) in 1 ml of dimethylformamide is stirred after the addition of 4 mg (0.05 mmol) of piperidine at room temperature for 45 min. The solvent is evaporated and the crude product is reacted without further purification.