Hydrochloric Acid → Benzyl((4S)-5-[(3-amino-2-hydroxypropyl)amino]-4-{[(benzyloxy)carbonyl]amino}-5-oxopentyl)carbamate hydrochloride

HRID 269688ノート

反応式

HRID 269688 の反応式
[ClH:1].[CH2:2]([O:9][C:10](=[O:42])[NH:11][C@H:12]([C:27]([NH:29][CH2:30][CH:31]([OH:41])[CH2:32][NH:33]C(OC(C)(C)C)=O)=[O:28])[CH2:13][CH2:14][CH2:15][NH:16][C:17]([O:19]CC1C=CC=CC=1)=[O:18])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([N:16]([CH2:15][CH2:14][CH2:13][C@H:12]([NH:11][C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:42])[C:27]([NH:29][CH2:30][CH:31]([OH:41])[CH2:32][NH2:33])=[O:28])[C:17](=[O:18])[OH:19])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86625290Benzyl {(1S)-4-{[(benzyloxy)carbonyl]amino}-1-[({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)carbonyl]butyl}carbamate

生成物 1

HCID 69219437Benzyl((4S)-5-[(3-amino-2-hydroxypropyl)amino]-4-{[(benzyloxy)carbonyl]amino}-5-oxopentyl)carbamate hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

6.8 ml of a 4N solution of hydrogen chloride in dioxane are added to a solution of 0.263 g (0.46 mmol) of the compound from Example 258A in 1 ml of dioxane at 0° C. After 2 h at RT, the reaction solution is concentrated in vacuo and coevaporated with dichloromethane several times. The remaining solid is dried to constant weight under high vacuum.

後処理

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customThe remaining solid is dried to constant weight under high vacuum

出典と根拠

ORDレコード
ord-3d01529a49944a54b455c638c2d93029
出典データセット
uspto-grants-2008_11
特許番号
US07446102B2

反応ノート

読み込み中…