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N,N-Dimethylglycine hydrochloride → 4-[4-(Dimethylaminoacetyl)-piperazin-1-yl]aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethylglycine hydrochloride | HCID 75605 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 4-[4-(Dimethylaminoacetyl)-piperazin-1-yl]aniline | HCID 23071545 | — |
反応手順
1-(4-nitrophenyl)piperazine and N,N-dimethylglycine hydrochloride were allowed to undergo the reaction using WSC hydrochloride and HOBt in 1-methyl-2-pyrrolidone in the presence of triethylamine. The resulting compound was subjected to-catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 1-[4-(4-aminophenyl)piperazin-1-yl]-2-dimethylaminoethanone. NMR2: 2.30 (6H, s), 3.74-3.76 (4H, m), 6.64-6.68 (2H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449456B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-e95718d9ab524f7c8b6e020f9a0654ea |
| 出典メモ | uspto-grants-2008_11 |