1-Benzoyl-4-(4-methoxyphenyl)piperazine → 1-Benzoyl-4-(4-hydroxyphenyl)piperazine

HRID 269870ノート

反応式

HRID 269870 の反応式
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1.[C:23]([N:31]1[CH2:36][CH2:35][N:34]([C:37]2[CH:42]=[CH:41][C:40]([O:43]C)=[CH:39][CH:38]=2)[CH2:33][CH2:32]1)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:23]([N:31]1[CH2:32][CH2:33][N:34]([C:37]2[CH:38]=[CH:39][C:40]([OH:43])=[CH:41][CH:42]=2)[CH2:35][CH2:36]1)(=[O:30])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

参加物

3

反応物 2

HCID 26643311-Benzoyl-4-(4-methoxyphenyl)piperazineHCID 155270761-(4-Methoxyphenyl)-4-phenethylpiperazine

生成物 1

HCID 40862031-Benzoyl-4-(4-hydroxyphenyl)piperazine収率 76.7%

実験手順

Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 1-benzoyl-4-(4-methoxyphenyl)piperazine (193 mg), and the resulting crude product was purified on TLC (developer, chloroform: acetone=4:1) to provide 1-benzoyl-4-(4-hydroxyphenyl)piperazine (141 mg).

後処理

  1. customthe resulting crude product was purified on TLC (developer, chloroform: acetone=4:1)

出典と根拠

ORDレコード
ord-eff20b8044ec47d8907dbb69c9bd52ff
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

反応ノート

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