1-(3-Chloro-4-methoxymethoxyphenyl)-4-phenethylpiperazine → 2-[4-(3-Chloro-4-hydroxyphenyl)piperazin-1-yl]-1-phenylethan-1-one

HRID 269884ノート

反応式

HRID 269884 の反応式
ClC1C=C(N2CCN(CCC3C=CC=CC=3)CC2)C=CC=1OCOC.[Cl:26][C:27]1[CH:28]=[C:29]([N:37]2[CH2:42][CH2:41][N:40]([CH2:43][C:44]([C:46]3[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=3)=[O:45])[CH2:39][CH2:38]2)[CH:30]=[CH:31][C:32]=1[O:33]COC>>[Cl:26][C:27]1[CH:28]=[C:29]([N:37]2[CH2:38][CH2:39][N:40]([CH2:43][C:44]([C:46]3[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=3)=[O:45])[CH2:41][CH2:42]2)[CH:30]=[CH:31][C:32]=1[OH:33]

参加物

3

反応物 2

HCID 231114421-(3-Chloro-4-methoxymethoxyphenyl)-4-phenethylpiperazineHCID 231114742-[4-(3-Chloro-4-methoxymethoxyphenyl)piperazin-1-yl]-1-phenylethan-1-one

生成物 1

HCID 231114072-[4-(3-Chloro-4-hydroxyphenyl)piperazin-1-yl]-1-phenylethan-1-one収率 13.3%

実験手順

Production Example 28 was repeated except that 1-(3-chloro-4-methoxymethoxyphenyl)-4-phenethylpiperazine was replaced with 2-[4-(3-chloro-4-methoxymethoxyphenyl)piperazin-1-yl]-1-phenylethan-1-one (221 mg). Thus obtained crude product was purified on TLC (developer, chloroform: acetone=6:1) to provide 2-[4-(3-chloro-4-hydroxyphenyl)piperazin-1-yl]-1-phenylethan-1-one (26 mg).

後処理

  1. customThus obtained crude product
  2. customwas purified on TLC (developer, chloroform: acetone=6:1)

出典と根拠

ORDレコード
ord-0a72113bee674439ab4fb80d70472753
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

反応ノート

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