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HRID 269895作成日：2026年10月27日

1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → 4-[4-(3-Cyclo-pentylpropyl)piperazin-1-yl]-2-fluorophenol hydrochloride

https://huagongshe.com/reaction/269895

反応式

関与物質

役割名称HCID仕込み量
反応物1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazineHCID 23111408—
反応物1-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclopentylpropyl)piperazineHCID 23111413—
生成物4-[4-(3-Cyclo-pentylpropyl)piperazin-1-yl]-2-fluorophenol hydrochlorideHCID 23111453—

反応手順

Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-3-fluorophenyl)-4-(3-cyclopentylpropyl)-piperazine (494 mg), to provide 4-[4-(3-cyclo-pentylpropyl)piperazin-1-yl]-2-fluorophenol hydrochloride (398 mg).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07449466B2
出典データセットuspto-grants-2008_11
ORD IDord-63c34ff4ba224e64bbb6bf7a39c8b536
出典メモuspto-grants-2008_11