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1-Phenethylpiperazine → 1-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Phenethylpiperazine | HCID 79214 | — |
| 反応物 | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| 反応物 | 1-(3-Cyclohexylpropyl)piperazine | HCID 2737393 | — |
| 反応物 | 1-(Benzyloxy)-4-bromo-2-fluorobenzene | HCID 18757491 | — |
| 生成物 | 1-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine | HCID 23111415 | 111.4% |
反応手順
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-(2-phenylethyl)piperazine were replaced with 1-benzyloxy-4-bromo-2-fluorobenzene (1.42 g) and 1-(3-cyclo-hexylpropyl)piperazine (1.28 g), respectively, to provide crude 1-(4-benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine (2.31 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449466B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-c63e18e059fe474497463d85a52780e9 |
| 出典メモ | uspto-grants-2008_11 |