1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → 4-[4-(3-Cyclohexylpropyl)piperazin-1-yl]-2-fluorophenol hydrochloride

HRID 269898

反応式

HRID 269898 の反応式
C(OC1C=CC(N2CCN(CCCC3CCCCC3)CC2)=CC=1[Cl:30])C1C=CC=CC=1.C([O:38][C:39]1[CH:44]=[CH:43][C:42]([N:45]2[CH2:50][CH2:49][N:48]([CH2:51][CH2:52][CH2:53][CH:54]3[CH2:59][CH2:58][CH2:57][CH2:56][CH2:55]3)[CH2:47][CH2:46]2)=[CH:41][C:40]=1[F:60])C1C=CC=CC=1>>[ClH:30].[CH:54]1([CH2:53][CH2:52][CH2:51][N:48]2[CH2:49][CH2:50][N:45]([C:42]3[CH:43]=[CH:44][C:39]([OH:38])=[C:40]([F:60])[CH:41]=3)[CH2:46][CH2:47]2)[CH2:59][CH2:58][CH2:57][CH2:56][CH2:55]1

参加物

3

反応物 2

HCID 231114081-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazineHCID 231114151-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine

生成物 1

HCID 231114144-[4-(3-Cyclohexylpropyl)piperazin-1-yl]-2-fluorophenol hydrochloride

実験手順

Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)-piperazine (1.45 g), to provide 4-[4-(3-cyclohexylpropyl)piperazin-1-yl]-2-fluorophenol hydrochloride (1.17 g).

出典と根拠

ORDレコード
ord-a36d1ae40d554b45837fe84781e50f3f
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

関連ノート

読み込み中…