Piperazine → 1-(4-Benzyloxy-3-fluorophenyl)piperazine

HRID 269900

反応式

HRID 269900 の反応式
BrC1C=CC(OC)=C(C)C=1.[CH2:11]([O:18][C:19]1[CH:24]=[CH:23][C:22](Br)=[CH:21][C:20]=1[F:26])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[NH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH2:11]([O:18][C:19]1[CH:24]=[CH:23][C:22]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:21][C:20]=1[F:26])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 3

HCID 4837PiperazineHCID 6083154-Bromo-1-methoxy-2-methylbenzeneHCID 187574911-(Benzyloxy)-4-bromo-2-fluorobenzene

生成物 1

HCID 231114831-(4-Benzyloxy-3-fluorophenyl)piperazine収率 54.1%

実験手順

Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-(2-phenethyl)piperazine were replaced with 1-benzyloxy-4-bromo-2-fluorobenzene (6.742 g) and piperazine (12.404 g), respectively. The resulting crude product was purified on silica gel column chromatography (eluent, chloroform: methanol=2:1) to provide 1-(4-benzyloxy-3-fluorophenyl)piperazine (3.716 g).

後処理

  1. customThe resulting crude product was purified on silica gel column chromatography (eluent, chloroform: methanol=2:1)

出典と根拠

ORDレコード
ord-85b653a234ca4a8f98ef32221a83778e
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

関連ノート

読み込み中…