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1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → 2-Fluoro-4-[4-(3-phenylpropyl)piperazin-1-yl]phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine | HCID 23111408 | — |
| 反応物 | 1-(4-Benzyloxy-3-fluorophenyl)-4-(3-phenylpropyl)-piperazine | HCID 23111437 | — |
| 生成物 | 2-Fluoro-4-[4-(3-phenylpropyl)piperazin-1-yl]phenol | HCID 23111406 | 73.1% |
反応手順
Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-3-fluorophenyl)-4-(3-phenylpropyl)-piperazine (394 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=10:1) to provide 2-fluoro-4-[4-(3-phenylpropyl)piperazin-1-yl]phenol (224 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449466B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-afb87b17d5614531bf0bf79ebf153926 |
| 出典メモ | uspto-grants-2008_11 |