4-(3-Phenylpropyl)piperidine → 1-(2,5-Difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine

HRID 269913

反応式

HRID 269913 の反応式
BrC1C=CC(OC)=C(C)C=1.Br[C:12]1[C:17]([F:18])=[CH:16][C:15]([O:19][CH3:20])=[C:14]([F:21])[CH:13]=1.[C:22]1([CH2:28][CH2:29][CH2:30][CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[F:18][C:17]1[CH:16]=[C:15]([O:19][CH3:20])[C:14]([F:21])=[CH:13][C:12]=1[N:34]1[CH2:35][CH2:36][CH:31]([CH2:30][CH2:29][CH2:28][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:32][CH2:33]1

参加物

4

反応物 3

HCID 876784-(3-Phenylpropyl)piperidineHCID 6083154-Bromo-1-methoxy-2-methylbenzeneHCID 27249834-Bromo-2,5-difluoroanisole

生成物 1

HCID 231115061-(2,5-Difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine収率 33.7%

実験手順

Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-(2-phenethyl)piperazine were replaced with 4-bromo-2,5-difluoroanisole (446 mg) and 4-(3-phenylpropyl)-piperidine (1.220 g), respectively. The resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=8:1) to provide 1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine (233 mg).

後処理

  1. customThe resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=8:1)

出典と根拠

ORDレコード
ord-d6123d46385f408a9055741a7d9c4e2a
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

関連ノート

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