Methoxymethyl-triphenylphosphonium chloride → HCID 67526767、化合物

HRID 269917

反応式

HRID 269917 の反応式
[Cl-].COC[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.FC1C=C(OC)C(F)=CC=1N1CCC(=O)CC1.[Br-].[CH2:42]([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1.[F:69][C:70]1[CH:75]=[C:74]([O:76][CH3:77])[C:73]([F:78])=[CH:72][C:71]=1[N:79]1[CH2:84][CH2:83][CH:82]([CH:85]=O)[CH2:81][CH2:80]1>>[F:69][C:70]1[CH:75]=[C:74]([O:76][CH3:77])[C:73]([F:78])=[CH:72][C:71]=1[N:79]1[CH2:84][CH2:83][CH:82](/[CH:85]=[CH:42]\[CH2:43][C:44]2[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=2)[CH2:81][CH2:80]1

参加物

5

反応物 4

HCID 2723798Methoxymethyl-triphenylphosphonium chlorideHCID 10863251Phenethyltriphenylphosphonium bromideHCID 231114661-(2,5-Difluoro-4-methoxyphenyl)piperidin-4-oneHCID 231115011-(2,5-Difluoro-4-methoxyphenyl)-4-piperidinecarbaldehyde

生成物 1

HCID 67526767HCID 67526767、化合物収率 78.6%

実験手順

Production Example 74 was repeated except that methoxymethyltriphenylphosphonium chloride and 1-(2,5-difluoro-4-methoxyphenyl)piperidin-4-one were replaced with phenethyltri-phenylphosphonium bromide (133 mg) and 1-(2,5-difluoro-4-methoxyphenyl)-4-piperidinecarbaldehyde (35 mg), respectively, and the resulting crude product was purified on TLC (developer, hexane: ethyl acetate=10:1) to provide (Z)-1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenyl-1-propen-1-yl)piperidine (37 mg).

後処理

  1. customrespectively, and the resulting crude product was purified on TLC (developer, hexane: ethyl acetate=10:1)

出典と根拠

ORDレコード
ord-67f811637d1746b9803a3db98e54a5be
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

関連ノート

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