1-Bromooctane → 1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine

HRID 269928

反応式

HRID 269928 の反応式
C(OC1C=CC(N2CCNCC2)=CC=1F)C1C=CC=CC=1.C(Br)CCCCCCC.[F:31][C:32]1[CH:37]=[C:36]([O:38][CH3:39])[C:35]([F:40])=[CH:34][C:33]=1[N:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1.[CH:47]1([CH2:53][CH2:54][CH2:55]Cl)[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]1>>[CH:47]1([CH2:53][CH2:54][CH2:55][N:44]2[CH2:45][CH2:46][N:41]([C:33]3[CH:34]=[C:35]([F:40])[C:36]([O:38][CH3:39])=[CH:37][C:32]=3[F:31])[CH2:42][CH2:43]2)[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]1

参加物

5

反応物 4

HCID 81401-BromooctaneHCID 70762(3-Chloropropyl)cyclohexaneHCID 231114831-(4-Benzyloxy-3-fluorophenyl)piperazineHCID 231114921-(2,5-Difluoro-4-methoxyphenyl)piperazine

生成物 1

HCID 231114261-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine収率 97.1%

実験手順

Production Example 38 was repeated except that 1-(4-benzyloxy-3-fluorophenyl)piperazine and n-octyl bromide were replaced with 1-(2,5-difluoro-4-methoxyphenyl)piperazine (228 mg) and 3-cyclohexylpropyl chloride (161 mg). The resulting crude product was purified on silica gel column chromatography (eluent, ethyl acetate) to provide 1-(3-cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (342 mg).

後処理

  1. customThe resulting crude product was purified on silica gel column chromatography (eluent, ethyl acetate)

出典と根拠

ORDレコード
ord-644ec63d6cc74fe2a71d0683d60d8240
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

関連ノート

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