1-Bromooctane → 3-[4-(2,5-Difluoro-4-methoxyphenyl)piperazin-1-yl]-1-phenylpropan-1-one

HRID 269931

反応式

HRID 269931 の反応式
C(OC1C=CC(N2CCNCC2)=CC=1F)C1C=CC=CC=1.C(Br)CCCCCCC.[F:31][C:32]1[CH:37]=[C:36]([O:38][CH3:39])[C:35]([F:40])=[CH:34][C:33]=1[N:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1.Cl[CH2:48][CH2:49][C:50]([C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:51]>>[F:31][C:32]1[CH:37]=[C:36]([O:38][CH3:39])[C:35]([F:40])=[CH:34][C:33]=1[N:41]1[CH2:46][CH2:45][N:44]([CH2:48][CH2:49][C:50]([C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)=[O:51])[CH2:43][CH2:42]1

参加物

5

反応物 4

HCID 81401-BromooctaneHCID 702953-ChloropropiophenoneHCID 231114831-(4-Benzyloxy-3-fluorophenyl)piperazineHCID 231114921-(2,5-Difluoro-4-methoxyphenyl)piperazine

生成物 1

HCID 231114253-[4-(2,5-Difluoro-4-methoxyphenyl)piperazin-1-yl]-1-phenylpropan-1-one収率 101.4%

実験手順

Production Example 38 was repeated except that 1-(4-benzyloxy-3-fluorophenyl)piperazine and n-octyl bromide were replaced with 1-(2,5-difluoro-4-methoxyphenyl)piperazine (228 mg) and 3-chloro-1-phenylpropan-1-one (169 mg), to provide crude 3-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]-1-phenylpropan-1-one (365 mg).

出典と根拠

ORDレコード
ord-a08f6455f53f4a40baf63ef1ca5caf58
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

関連ノート

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