戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 269934作成日：2026年10月27日

1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]butan-1-one → 1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-hydroxyphenyl)piperazin-1-yl]butan-1-one

https://huagongshe.com/reaction/269934

反応式

関与物質

役割名称HCID仕込み量
反応物1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]butan-1-oneHCID 23111410—
反応物1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazineHCID 23111426—
生成物1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-hydroxyphenyl)piperazin-1-yl]butan-1-oneHCID 2311145545.7%

反応手順

Production Example 94 was repeated except that 1-(3-cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine was replaced with 1-(4-tert-butylphenyl)-4-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]butan-1-one (330 mg). The resulting crude product was purified on TLC (developer, ethyl acetate: hexane=2:1) to provide 1-(4-tert-butylphenyl)-4-[4-(2,5-difluoro-4-hydroxyphenyl)piperazin-1-yl]butan-1-one (146 mg).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07449466B2
出典データセットuspto-grants-2008_11
ORD IDord-04100dbdd2e84cd0b5b8eed414d74221
出典メモuspto-grants-2008_11