1-(4-Methoxyphenyl)-4-phenethylpiperazine → 4-(2,5-Difluoro-4-hydroxyphenyl)-1-phenethylsulfonylpiperazine

HRID 269951ノート

反応式

HRID 269951 の反応式
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1.[F:23][C:24]1[CH:29]=[C:28]([O:30]C)[C:27]([F:32])=[CH:26][C:25]=1[N:33]1[CH2:38][CH2:37][N:36]([S:39]([CH2:42][CH2:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)(=[O:41])=[O:40])[CH2:35][CH2:34]1>>[F:23][C:24]1[CH:29]=[C:28]([OH:30])[C:27]([F:32])=[CH:26][C:25]=1[N:33]1[CH2:38][CH2:37][N:36]([S:39]([CH2:42][CH2:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)(=[O:41])=[O:40])[CH2:35][CH2:34]1

参加物

3

反応物 2

HCID 155270761-(4-Methoxyphenyl)-4-phenethylpiperazineHCID 231114704-(2,5-Difluoro-4-methoxyphenyl)-1-phenethylsulfonylpiperazine

生成物 1

HCID 231114164-(2,5-Difluoro-4-hydroxyphenyl)-1-phenethylsulfonylpiperazine収率 65.9%

実験手順

Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 4-(2,5-difluoro-4-methoxyphenyl)-1-phenethylsulfonylpiperazine (401 mg). The resulting crude product was purified on TLC (developer, hexane: ethyl acetate=2:1) to provide 4-(2,5-difluoro-4-hydroxyphenyl)-1-phenethylsulfonylpiperazine (255 mg).

後処理

  1. customThe resulting crude product was purified on TLC (developer, hexane: ethyl acetate=2:1)

出典と根拠

ORDレコード
ord-1c661cc12f434ab2a2af5a512cc27596
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

反応ノート

読み込み中…