関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline | HCID 45480181 | — |
| 反応物 | (R)-2-chloro-6-methyl-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine | HCID 59577867 | — |
| 試薬 | Sodium 2-methylbutan-2-olate | HCID 2733478 | — |
| 触媒 | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | (R)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-6-methyl-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepin-2-amine | HCID 49820859 | 0% |
反応手順
(R)-2-chloro-6-methyl-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine (0.05 g, 0.18 mmol), PALLADIUM(II) ACETATE (1.221 mg, 5.44 µmol) (1.6), 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (0.037 g, 0.18 mmol) (0.64), Tri-tert- butylphosphonium tetrafluoriborate (0.0043 g, 0.014 mmol, 6 mol%) and Na-t-amilate (0.022 g, 1.1 equ, 0.2 mmol) in 1 ml of dioxane was degaset over argone and heated in MW 120°C 30 min. No reaction. Experiment was not progressed.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-3a2eb97137e148aba58c08979aa7d29e |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
