Ethyl 2-aminobenzoate → Ethyl 2-(1H-pyrrol-1-yl)benzoate

HRID 270004ノート

反応式

HRID 270004 の反応式
[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH2:11])[CH3:2].CO[CH:15]1[CH2:19][CH2:18][CH:17](OC)O1>C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH:15]=[CH:19][CH:18]=[CH:17]1)[CH3:2]

参加物

4

反応物 2

HCID 6877Ethyl 2-aminobenzoateHCID 790982,5-Dimethoxytetrahydrofuran

生成物 1

HCID 12673310Ethyl 2-(1H-pyrrol-1-yl)benzoate

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a stirred solution of 2-amino benzoic acid ethyl ester (20 g; 121 mmol) in acetic acid (35 mL) was added 2,5-dimethoxytetrahydrofuran (19 g; 174 mmol). The reaction mixture was stirred for two hours at reflux. After evaporation of the solvent, the crude product was purified by flash column chromatography (methylene chloride) to give compound 2-pyrrol-1-yl-benzoic acid ethyl ester as a yellow oil. Rf=0.63 (methylene chloride); (22.2 g; 103 mmol; 85%)

後処理

  1. temperatureat reflux
  2. customAfter evaporation of the solvent
  3. customthe crude product was purified by flash column chromatography (methylene chloride)

出典と根拠

ORDレコード
ord-38830af035d44438b1b802bd7fffa03e
出典データセット
uspto-grants-2008_11
特許番号
US07449481B2

反応ノート

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