化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Anhydride → N-(4-fluoro-2-hydroxyphenyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 5-Fluoro-2-nitrophenol | HCID 9937 | — |
| 触媒 | Platinum | HCID 23939 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-(4-fluoro-2-hydroxyphenyl)acetamide | HCID 177738 | 87.4% |
反応手順
A mixture of 5-fluoro-2-nitrophenol (5 g, 31.8 mmol), acetic anhydride (4.86 g, 47.7 mmol) and platinum on carbon (5%, 200 mg) in methanol was hydrogenated at 35 psi for 3 hours. The catalyst was filtered off and the residue was purified by silica gel flash chromatography to give the subtitled compound (4.7 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449475B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-a26a1d68247b4745ab08f78a13da12b9 |
| 出典メモ | uspto-grants-2008_11 |