化工社化工社 化学情報印刷レポート · 研究参考用
4-Chlorophenyl Isocyanate → 3-Carbethoxy-4-(4-chlorophenylaminocarbonyl)thiomorpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorophenyl Isocyanate | HCID 7693 | — |
| 反応物 | Ethyl thiomorpholine-3-carboxylate | HCID 13604869 | — |
| 触媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 3-Carbethoxy-4-(4-chlorophenylaminocarbonyl)thiomorpholine | HCID 23343409 | 30.5% |
反応手順
Seven grams of 3-carbethoxythiomorpholine and 6.5 g of 4-chlorophenyl isocyanate were added to 60 ml of hexanes containing 10 drops of triethylamine as a catalyst. A mild exothermic reaction took place as the reactants mixed. After the mixture cooled to room temperature, the precipitate was collected by filtration and recrystallized from a mixture of methylene chloride and ether to give 4 g of 3-carbethoxy-4-(4-chlorophenylaminocarbonyl)thiomorpholine, mp 152.5°-154.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04220465 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-9654ff91796547b1bc485f42a54b4c55 |
| 出典メモ | uspto-grants-1980_09 |