Cyclopropylamine → N-Cyclopropyl-4-fluoro-2-hydroxybenzamide

HRID 270063ノート

反応式

HRID 270063 の反応式
[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=O)=[C:4]([OH:12])[CH:3]=1.[CH:13]1([NH2:16])[CH2:15][CH2:14]1>>[CH:13]1([NH:16][C:6](=[O:8])[C:5]2[CH:10]=[CH:11][C:2]([F:1])=[CH:3][C:4]=2[OH:12])[CH2:15][CH2:14]1

参加物

3

反応物 2

HCID 69828CyclopropylamineHCID 2775386Methyl 4-fluorosalicylate

生成物 1

HCID 68961144N-Cyclopropyl-4-fluoro-2-hydroxybenzamide

実験手順

A suspension of methyl 4-fluoro-2-hydroxybenzoate (510 mg, 3.0 mmol) in cyclopropylamine (5 mL) was stirred at room temperature overnight when it became a clear solution. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum ether) to give the subtitled compound (493 mg).

後処理

  1. customThe volatiles were removed in vacuo
  2. customthe residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum ether)

出典と根拠

ORDレコード
ord-bf55cd4353ca46b28da7938e0e45cb3d
出典データセット
uspto-grants-2008_11
特許番号
US07449475B2

反応ノート

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