Cyclopropylamine → HCID 28390698、化合物

HRID 270065

反応式

HRID 270065 の反応式
[OH:1][C:2]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[CH:14]1([NH2:17])[CH2:16][CH2:15]1>>[CH:14]1([NH:17][C:4](=[O:6])[C:3]2[CH:8]=[CH:9][C:10]([O:12][CH3:13])=[CH:11][C:2]=2[OH:1])[CH2:16][CH2:15]1

参加物

3

反応物 2

HCID 69828CyclopropylamineHCID 79523Methyl 4-methoxysalicylate

生成物 1

HCID 28390698HCID 28390698、化合物

実験手順

A suspension of methyl 2-hydroxy-4-methoxybenzoate (5.1 g, 28.0 mmol) in cyclopropyl amine 24 mL) was stirred at room temperature for 5 days. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-60% ethyl acetate in petroleum ether) to give the subtitled compound (1.8 g).

後処理

  1. customThe volatiles were removed in vacuo
  2. customthe residue was purified by silica gel flash chromatography (0-60% ethyl acetate in petroleum ether)

出典と根拠

ORDレコード
ord-28b3b4d48a0f4850b7c740c5ce9c9a29
出典データセット
uspto-grants-2008_11
特許番号
US07449475B2

関連ノート

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