Trifluoroacetic acid water → 2-Acetylamino-5-benzoyloxyphenol

HRID 270069ノート

反応式

HRID 270069 の反応式
[C:1]([O:9][C:10]1[CH:19]=[CH:18][C:13]2[N:14]=[C:15]([CH3:17])[O:16][C:12]=2[CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=[O:23].O>C([O-])(O)=O.[Na+]>[C:1]([O:9][C:10]1[CH:19]=[CH:18][C:13]([NH:14][C:15](=[O:23])[CH3:17])=[C:12]([OH:16])[CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 22392675Trifluoroacetic acid waterHCID 689598582-Methyl-6-benzoyloxybenzoxazole

生成物 1

HCID 689576202-Acetylamino-5-benzoyloxyphenol

試薬・触媒・溶媒 1

HCID 516892Sodium Bicarbonate溶媒

実験手順

To a solution of 2-methyl-1,3-benzoxazol-6-yl benzoate (5.05 g, 20 mmol) in THE (100 mL) a mixture trifluoroacetic acid/water (4 ml/10 mL) was added. The reaction mixture was stirred at room temperature for 16 h, then saurated aqueous NaHCO3 (150 mL) was added. The mixture was extracted with ethyl acetate (150 mL), dried over Na2SO4, filtered and concentrated in vacuo to give the subtitled compound.

後処理

  1. additionwas added
  2. extractionThe mixture was extracted with ethyl acetate (150 mL)
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-ba9e49b9af9e45a3a88a7ea6a9ac49b6
出典データセット
uspto-grants-2008_11
特許番号
US07449475B2

反応ノート

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