Acetic Anhydride → N-(4-Chloro-2-hydroxyphenyl)acetamide

HRID 270073

反応式

HRID 270073 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[C:10](OC(=O)C)(=[O:12])[CH3:11]>CO>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:10](=[O:12])[CH3:11])=[C:3]([OH:9])[CH:4]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 915912-Amino-5-chlorophenol

生成物 1

HCID 177739N-(4-Chloro-2-hydroxyphenyl)acetamide収率 91.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a suspension of 2-amino-5-chlorophenol (1.01 g, 7.0 mmol) in methanol (10 mL) was added acetic anhydride (1.08 g, 10.55 mmol) and the reaction mixture was stirred at room temperature for 30 min. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (hexane:ethyl acetate 5:2) to give the subtitled compound (1.19 g).

後処理

  1. customThe volatiles were removed in vacuo
  2. customthe residue was purified by silica gel flash chromatography (hexane:ethyl acetate 5:2)

出典と根拠

ORDレコード
ord-c24fa62b13a64ab6b70ce5338142fb9d
出典データセット
uspto-grants-2008_11
特許番号
US07449475B2

関連ノート

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