Acetic Anhydride → N-(4-Chloro-2-hydroxyphenyl)acetamide
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[C:10](OC(=O)C)(=[O:12])[CH3:11]>CO>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:10](=[O:12])[CH3:11])=[C:3]([OH:9])[CH:4]=1参加物
4
実験手順
To a suspension of 2-amino-5-chlorophenol (1.01 g, 7.0 mmol) in methanol (10 mL) was added acetic anhydride (1.08 g, 10.55 mmol) and the reaction mixture was stirred at room temperature for 30 min. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (hexane:ethyl acetate 5:2) to give the subtitled compound (1.19 g).
後処理
- customThe volatiles were removed in vacuo
- customthe residue was purified by silica gel flash chromatography (hexane:ethyl acetate 5:2)
出典と根拠
- ORDレコード
- ord-c24fa62b13a64ab6b70ce5338142fb9d
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07449475B2
反応ノート
読み込み中…