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Thionyl Chloride → {[tert-Butyl(diphenyl)silyl]oxy}acetyl Chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-((tert-Butyldiphenylsilyl)oxy)acetic acid | HCID 11141564 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | {[tert-Butyl(diphenyl)silyl]oxy}acetyl Chloride | HCID 19090360 | — |
反応手順
In a 500ml round-bottom flask was mixed {[tert-butyl(diphenyl)silyl]oxy}acetic acid (17g, 54.0mmoles, 1eq), thionyl chloride (11.7g, 0.162moles, 3eq) and dry CH2Cl2(120ml, 0.45M). This mixture was refluxed for 5hours. After cooling to room temperature the volatiles were removed in vacuo. The resulting residue washed twice with toluene and the toluene was subsequently removed in vacuo to remove excess thionyl chloride. This resulted in 18g (100%) of titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449468B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-4a51facb11084786b90bd8496d7c1722 |
| 出典メモ | uspto-grants-2008_11 |