Triphenylphosphine → 3-Methyl-4-methoxybenzyl triphenylphosphonium chloride

HRID 270156

反応式

HRID 270156 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][Cl:10])=[CH:5][C:4]=1[CH3:11].[C:12]1([P:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[Cl-:10].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][P+:18]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:5][C:4]=1[CH3:11]

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 1437424-Methoxy-3-methylbenzyl chloride

生成物 1

HCID 461800353-Methyl-4-methoxybenzyl triphenylphosphonium chloride収率 71%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a 250ml round-bottom flask equipped with a magnetic stir-bar and N2inlet was added 4-(Chloromethyl)-2-methylphenyl methyl ether (2.59g, 15.18mmoles, 1eq), dry toluene (50ml, 0.3M) and triphenylphosphine (3.98g, 15.18mmoles, 1eq). The reaction mixture was refluxed overnight. After cooling to room temperature the solvent was removed in vacuo, the residue washed with hexanes and the solid/liquid mixture was filtered to yield 4.48g (71%) of solid product.

後処理

  1. customTo a 250ml round-bottom flask equipped with a magnetic stir-bar
  2. temperatureThe reaction mixture was refluxed overnight
  3. customwas removed in vacuo
  4. washthe residue washed with hexanes
  5. filtrationthe solid/liquid mixture was filtered

出典と根拠

ORDレコード
ord-a8fd80fb3ecd46b39c18bdf4df3422d0
出典データセット
uspto-grants-2008_11
特許番号
US07449468B2

関連ノート

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