化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → {4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | N-(2-Methoxyethyl)ethylamine | HCID 546877 | — |
| 反応物 | HCID 22313931 | HCID 22313931 | — |
| 反応物 | {4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine | HCID 22314065 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | {4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine hydrochloride | HCID 22314064 | — |
反応手順
In analogy to example 3.1, 6-(4-Bromo-butoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole and N-(2-Methoxyethyl)ethylamine were converted to {4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine which was converted to the hydrochloride by treatment with HCl in methanol to yield {4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine hydrochloride as light yellow oil, MS: 463(MH+, 1Br).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449483B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-349c7ea7eb594fed8e4695d0d8cc7c61 |
| 出典メモ | uspto-grants-2008_11 |