Propargyl bromide → 3-(Prop-2-ynyloxy)pyridine

HRID 27039

反応式

HRID 27039 の反応式
[OH:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.C[O-].[Na+].[CH2:11](Br)[C:12]#[CH:13]>CN(C)C=O>[CH2:13]([O:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1)[C:12]#[CH:11]

参加物

5

反応物 3

HCID 7842Propargyl bromideHCID 79713-HydroxypyridineHCID 10942334Sodium Methoxide

生成物 1

HCID 114236223-(Prop-2-ynyloxy)pyridine収率 34%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a mixture of 9.5 g (0.1 mole) 3-hydroxypyridine, 5.2 g (0.1 mole) sodium methylate and 150 ml N,N-dimethylformamide, there was added 12.0 g (0.1 mole) propargyl bromide at room temperature over a two hour period. Most of the solvent was removed under reduced pressure. The residue was taken up with 200 ml methylene chloride and 100 ml water, the layers were separated and the methylene chloride evaporated to give 4.5 g 3-(2-propynyloxy)pyridine, yield 34%.

後処理

  1. customMost of the solvent was removed under reduced pressure
  2. customthe layers were separated
  3. customthe methylene chloride evaporated

出典と根拠

ORDレコード
ord-6783eeea9c804d0b933662c82c1126bf
出典データセット
uspto-grants-1980_09
特許番号
US04220577

関連ノート

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