Piperazine → 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine
反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[N:3]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(N(CC)CC)C>CN(C=O)C>[F:9][C:8]([F:11])([F:10])[C:4]1[N:3]=[C:2]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH:7]=[CH:6][CH:5]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
A solution of 2-chloro-6-(trifluoromethyl)pyridine (1.0 g, 5.5 mmol), piperazine (1.4 g, 16.0 mmol), and triethylamine (1.5 mL, 11.0 mmol) were mixed in DMF (10 mL) in a dealed tube. The mixture was heated at 100° C. overnight. The reaction mixture was concentrated and chromatographed on silica gel (ethyl acetate to EA/MeOH/Et3N=9:1:0.5) to give 1.05 g of the desired product. MS calculated for C10H12F3N3: (M+H) 232.1; found 232.1.
後処理
- concentrationThe reaction mixture was concentrated
- customchromatographed on silica gel (ethyl acetate to EA/MeOH/Et3N=9:1:0.5)
出典と根拠
- ORDレコード
- ord-019e2bcf7d3c4da8a7354b28da12f137
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07449467B2
反応ノート
読み込み中…