Ethanol → HCID 86585161、化合物
反応式
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[S:9])=[CH:6][N:5]=[C:4]([CH3:13])[N:3]=1.[CH3:14][NH2:15].C(O)C.O>ClCCl>[CH3:14][NH:15][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[S:9])=[CH:6][N:5]=[C:4]([CH3:13])[N:3]=1参加物
6
実験手順
To a solution of ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (Aldrich, 20 g, 86 mmol) in 250 mL of dichloromethane at 0° C. was added slowly solution of methylamine in ethanol (33%, 35 mL 281 mmol). After stirring for 30 minutes, water (150 mL) was added and the phases were separated. The organic phase was dried (MgSO4) and filtered. The filtrate was evaporated under reduced pressure to give 19 g of the ethyl 4-methylamino-2-methylthiopyrimidine-5-carboxylate as a white solid.
後処理
- customthe phases were separated
- dry with materialThe organic phase was dried (MgSO4)
- filtrationfiltered
- customThe filtrate was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-1d43ee9774a045f89a3318a14c4be6fb
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07449581B2
反応ノート
読み込み中…