Water → [(2,4-Difluoro-phenyl)-methyl-amino]-acetic acid methyl ester

HRID 270727ノート

反応式

HRID 270727 の反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[NH:4][CH3:5].C([O-])([O-])=O.[K+].[K+].Br[CH2:18][C:19]([O:21][CH3:22])=[O:20].O>CN1C(=O)CCC1>[CH3:22][O:21][C:19](=[O:20])[CH2:18][N:4]([C:3]1[CH:6]=[CH:7][C:8]([F:10])=[CH:9][C:2]=1[F:1])[CH3:5]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 27370232,4-difluoro-N-methylaniline

生成物 1

HCID 20627003[(2,4-Difluoro-phenyl)-methyl-amino]-acetic acid methyl ester

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

To a mixture of the 2,4-Difluoro-N-methylaniline (Avacado Research Chemical, Heysham UK) (1.43 g, 10 mmole) in NMP, and K2CO3, was added methyl bromoacetate (0.945 ml, 10 mmole) and stirred at room temperature for 24 hours. The reaction mixture was added to water and extracted with ethyl acetate (3×50 ml), the organic extracts were washed 6× with water, dried (MgSO4) and evaporated to give the product as a oil.

後処理

  1. extractionextracted with ethyl acetate (3×50 ml)
  2. washthe organic extracts were washed 6× with water
  3. dry with materialdried (MgSO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-0cd90cc2da65448597dfde384bb31d0b
出典データセット
uspto-grants-2008_11
特許番号
US07449581B2

反応ノート

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