Dimethylformamide → HCID 178434610、化合物

HRID 270786ノート

反応式

HRID 270786 の反応式
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([F:10])([F:9])[F:8])[NH:4][N:3]=1.CN(C=O)C.[Cl:16]N1C(=O)CCC1=O>O>[Cl:16][C:6]1[C:2]([CH3:1])=[N:3][NH:4][C:5]=1[C:7]([F:10])([F:9])[F:8]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 31398ChlorosuccinimideHCID 1390771H-Pyrazole, 3-methyl-5-(trifluoromethyl)-

生成物 1

HCID 178434610HCID 178434610、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

3-methyl-5-trifluoromethylpyrazole was taken into dry DMF (20 mL) and N-chloro succinimide (1.78 g) was added in portions. The mixture was then heated at 70° C. for 22 h, cooled to room temperature, and then water (100 mL) was added and the mixture extracted with ethyl acetate (4×25 mL). The organic layer was washed with water and brine and dried with Na2SO4. Evaporation of the solvent afforded the title compound.

後処理

  1. additionwas added in portions
  2. temperaturecooled to room temperature
  3. extractionthe mixture extracted with ethyl acetate (4×25 mL)
  4. washThe organic layer was washed with water and brine
  5. dry with materialdried with Na2SO4
  6. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-54f8eead3ef64bd1b4ef90c1484c3d55
出典データセット
uspto-grants-2008_11
特許番号
US07449576B1

反応ノート

読み込み中…