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Dimethylformamide → 1-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-(4-chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(Chloroacetyl)-4-(4-chlorophenyl)piperazine | HCID 4053957 | — |
| 反応物 | HCID 178506302 | HCID 178506302 | — |
| 溶媒 | Ethyl acetate hexane | HCID 21226206 | — |
| 生成物 | 1-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-(4-chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone | HCID 21070997 | — |
反応手順
Protocol T was followed using 4-Chloro-5-phenyl-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3); 7.82-7.84 (m, 2H), 7.4-7.48 (m, 3H), 6.9-7.04 (m, 2H), 6.88-6.94 (m, 2H), 5.22 (s, 1H), 3.76-3.88 (m, 2H), 3.6-3.68 (m, 2H), 3.1-3.22 (m, 4H). 13C NMR (400 MHz, CDCl3): 164.2, 130.4, 128, 126, 118.2, 116.4, 52.2, 50, 44, 41.8.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449576B1 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-06afe5d6bf594ffa90ff0542e558e568 |
| 出典メモ | uspto-grants-2008_11 |