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Piperazine → 1-(Piperazin-1-yl)propan-1-one hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | Propionamide | HCID 6578 | — |
| 反応物 | 4-Propanoylpiperazine-1-carbonyl chloride | HCID 14369520 | — |
| 触媒 | Iodine | HCID 807 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 1-(Piperazin-1-yl)propan-1-one hydrochloride | HCID 13017829 | — |
反応手順
The 1-chlorocarbonyl-4-propionylpiperazine used as starting material can be prepared as follows. Anhydrous piperazine (120 g.) and propionamide (m.p. 80° C., 102 g.) in anhydrous xylene (100 cm3) are heated under reflux for 48 hours in the presence of iodine (0.9 g.) to give 1-propionylpiperazine hydrochloride (153.0 g.), m.p. 165° C. 1-Propionylpiperazine is liberated from its hydrochloride by the action of an excess of ammonia in diethyl ether. The ammonium chloride formed is separated by filtration and the 1-propionylpiperazine is isolated by evaporation of the ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04220646 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-18f5dfb69f5b4bd8898f781342fac926 |
| 出典メモ | uspto-grants-1980_09 |