関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | 1-(Piperazin-1-yl)propan-1-one | HCID 3844375 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-Propanoylpiperazine-1-carbonyl chloride | HCID 14369520 | 98.8% |
反応手順
A solution of phosgene (45.0 g.) in anhydrous toluene (500 cm3) and 1-propionylpiperazine (129.0 g.) are added simultaneously to anhydrous toluene (500 cm3), while the temperature is maintained at about -5° C. 1-Chlorocarbonyl-4-propionylpiperazine (92.0 g.), m.p. about 45° C., is thus obtained. After one hour's stirring at 2° C., the 1-propionylpiperazine hydrochloride formed is separated by filtration and, after evaporation of the filtrate under reduced pressure (20 mm.Hg) 1-chlorocarbonyl-4-propionyl-piperazine is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04220646 |
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| 出典データセット | uspto-grants-1980_09 |
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| ORD ID | ord-454a4d1d047944559f6b3e3e7e08114b |
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| 出典メモ | uspto-grants-1980_09 |
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