化工社化工社 化学情報印刷レポート · 研究参考用
Cesium carbonate → 1-(Difluoromethoxy)-4-ethynylbenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | {[4-(Difluoromethoxy)phenyl]ethynyl}(trimethyl)silane | HCID 68699091 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 1-(Difluoromethoxy)-4-ethynylbenzene | HCID 2778497 | 97% |
反応手順
A solution of {[4-(difluoromethoxy)phenyl]ethynyl}(trimethyl)silane (10.0 g, 41.7 mmol) in MeOH/CH2Cl2 (1/1) was treated with cesium carbonate (16.3 g, 50 mmol) at room temperature, stirred for 1.5 h, diluted with CH2Cl2 and filtered through a pad of silica gel. The filtrate was concentrated to dryness to give the title compound (6.8 g, 97%) as an oil. MS (+) EI: 168.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07452885B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-a871ee9c353348c1b6690fe365083eea |
| 出典メモ | uspto-grants-2008_11 |