Cysteamine → 4-Bromo-3-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide

HRID 27114

反応式

HRID 27114 の反応式
[Br:1][C:2]1[C:3]([CH2:7]Br)=[N:4][S:5][CH:6]=1.[NH2:9][CH2:10][CH2:11][SH:12]>>[BrH:1].[Br:1][C:2]1[C:3]([CH2:7][S:12][CH2:11][CH2:10][NH2:9])=[N:4][S:5][CH:6]=1

参加物

3

反応物 2

HCID 6058CysteamineHCID 205576434-Bromo-3-(bromomethyl)-1,2-thiazole

生成物 1

HCID 205500984-Bromo-3-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide

実験手順

The reaction of 4-bromo-3-(bromomethyl)isothiazole (8.5 g) with cysteamine (from cysteamine hydrochloride (3.76 g)) was performed under conditions similar to those described in Example 72. From the reaction there was obtained 4-bromo-3-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide, which, following recrystallisation from ethanol-ether and acetonitrile, gave needles (4.05 g), m.p. 111°-112°. The amine base (2.73 g) was isolated by basification with sodium hydroxide and extraction with chloroform.

後処理

  1. customFrom the reaction there

出典と根拠

ORDレコード
ord-70d99b2e6c4647d0b9f7817d1f0eb729
出典データセット
uspto-grants-1980_09
特許番号
US04220652

関連ノート

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