Ethanol → Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

HRID 271235ノート

反応式

HRID 271235 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[CH2:17](O)[CH3:18]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:9]2)=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 702EthanolHCID 29126521-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

生成物 1

HCID 21935588Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

反応条件

温度
0 °C

実験手順

1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (unknown amount) was dissolved in 20 ml ethanol and cooled to 0° C. HCl gas was bubbled into the solution until the solution became red in color. The reaction was allowed to warm to room temperature and stir ovenight. The solvent was removed to yield ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate (M+1=251.93).

後処理

  1. customHCl gas was bubbled into the solution until the solution
  2. temperatureto warm to room temperature
  3. customThe solvent was removed

出典と根拠

ORDレコード
ord-3c074810df3c4d3c99c269f3996b7ca9
出典データセット
uspto-grants-2008_11
特許番号
US07452889B2

反応ノート

読み込み中…