Tributyltin azide → HCID 178498353、化合物
反応式
[CH3:1][O:2][C:3](=[O:14])[C:4]1[C:9]([Cl:10])=[CH:8][C:7]([C:11]#[N:12])=[CH:6][C:5]=1[Cl:13].[N:15]([Sn](CCCC)(CCCC)CCCC)=[N+:16]=[N-:17]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3](=[O:14])[C:4]1[C:5]([Cl:13])=[CH:6][C:7]([C:11]2[NH:17][N:16]=[N:15][N:12]=2)=[CH:8][C:9]=1[Cl:10]参加物
4
反応条件
- 温度
- 100 °C
実験手順
The mixture of 185 mg of 2,6-dichloro-4-cyanobenzoic acid methylester, 266 mg of azidotributyltin and 5 ml of toluene was stirred at 100° C. for 3 days. The reaction mixture was concentrated and diluted with ethyl acetate. After Celite filtration, the filtrate was concentrated and the residue was purified by reverse phase HPLC to obtain the title compound.
後処理
- concentrationThe reaction mixture was concentrated
- additiondiluted with ethyl acetate
- filtrationAfter Celite filtration
- concentrationthe filtrate was concentrated
- customthe residue was purified by reverse phase HPLC
出典と根拠
- ORDレコード
- ord-2fdbb417753a459193cf47bd0c0624b8
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07452905B2
反応ノート
読み込み中…