Bromine → 5-Bromo-6-chloropyrimidine-2,4-diol

HRID 271422

反応式

HRID 271422 の反応式
[Cl:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH:3]=1.[Br:10]Br>O>[Br:10][C:3]1[C:4](=[O:9])[NH:5][C:6](=[O:8])[NH:7][C:2]=1[Cl:1]

参加物

4

反応物 2

HCID 24408BromineHCID 732726-Chlorouracil

生成物 1

HCID 5898345-Bromo-6-chloropyrimidine-2,4-diol収率 61.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirring and refluxing solution of 6-chloropyrimidine-2,4(1H,3H)-dione (10.0 g, 68.25 mmol) in water (100 mL) was added bromine (4 mL, 79.84 mmol)) over 10 min. The colorless precipitate that formed was collected by filtration, washed with water (50 mL×2), and dried in a vacuum oven at 50° C. overnight, to obtain 9.4 g of the title compound as a white solid. HPLC/MS: retention time=1.05 min, [M+H]30 =225.

後処理

  1. customThe colorless precipitate that formed
  2. filtrationwas collected by filtration
  3. washwashed with water (50 mL×2)
  4. customdried in a vacuum oven at 50° C. overnight

出典と根拠

ORDレコード
ord-36f4b4f8f9444ba68960dafb5f4540de
出典データセット
uspto-grants-2008_11
特許番号
US07452892B2

関連ノート

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