2-((4-Chlorophenyl)amino)acetic acid → N-[2-(3,4-dibenzyloxyphenyl)ethyl]-2-(p-chloroanilino)acetamide

HRID 27168

反応式

HRID 27168 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:17]=1[O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:12][CH2:13][NH2:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:26][C:27]1[CH:37]=[CH:36][C:30]([NH:31][CH2:32][C:33](O)=[O:34])=[CH:29][CH:28]=1>C1C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:12][CH2:13][NH:14][C:33](=[O:34])[CH2:32][NH:31][C:30]2[CH:36]=[CH:37][C:27]([Cl:26])=[CH:28][CH:29]=2)[CH:15]=[CH:16][C:17]=1[O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 2307172-((4-Chlorophenyl)amino)acetic acidHCID 4238693,4-Bis(benzyloxy)phenethylamine hydrochloride

生成物 1

HCID 20460567N-[2-(3,4-dibenzyloxyphenyl)ethyl]-2-(p-chloroanilino)acetamide収率 50.4%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
190 °C

実験手順

A mixture of 3,4-dibenzyloxyphenethylamine (36.2 g) and p-chloroanilinoacetic acid (20 g) was stirred for 3 hours at 190° C. The reaction mixture was dissolved in benzene. The solution was washed with a diluted potassium carbonate aqueous solution and dried. The solvent was distilled off from the benzene solution and the residue obtained was purified by column chromatography on silica gel to give N-[2-(3,4-dibenzyloxyphenyl)ethyl]-2-(p-chloroanilino)acetamide (27.2 g), mp 121° C.

後処理

  1. washThe solution was washed with a diluted potassium carbonate aqueous solution
  2. customdried
  3. distillationThe solvent was distilled off from the benzene solution
  4. customthe residue obtained
  5. customwas purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-d32a625541c54a508541c94c4e741306
出典データセット
uspto-grants-1980_09
特許番号
US04220647

関連ノート

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